The Church in Agira dedicated to Sant’Antonio di Padova was built in 1505 and initially dedicated to Santa Maria Vergine. It took its current name when it was renovated in 1567.
In 1680, the bell tower with its characteristic maiolica spire was erected, while the facade dates from the second half of the 18th century, as does the interior. In 1869, a fire destroyed part of the frescoes on the vaults, the main altar, and the choir.
Once the restoration works were completed, they revealed the existence of a previous phase of the church, corresponding in plan to the central nave.
Inside, there is a small painting of the Epiphany on marble, likely the work of a Roman Mannerist from the 16th century, the wooden statue of San Silvestro from 1604, and the marble statue of the Madonna dei Poveri, dating back to the mid-16th century.